GoW Viper Venom 5% Serum
Synake [Viper Venom as we like to call it] is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the affect of Waglerin 1, A peptide that is found in the
venom of the Temple Viper, Tropidolaemus wagleri.
Used for its excellent anti-wrinkle active compound which smoothes mimic wrinkles in a short period of time.
NOTE: this serum will give an immediate Botox like effect but it is also cumulative. Give it 30 days for the full effect. This product should be used ONLY for spot treatments, i.e.
laughs lines, forehead, neck, crow's
Method of Application
This is a Botox alternative, because it is topical, however, (and this is good) you can not do any permanent damage.Now, if you put it just where the lines are, it will not work to the
"optimum capacity" of it's abilities. You have to go about it like a medical professional. The muscles are where you need to use it, not the wrinkles. That would mean, around the IIs -- both
sides, over either eyebrow (for a start). The best way I can describe it: Make a face, putting your eyebrows together, like a frown -- put your fingertips along your forehead, and "feel" the
muscles move. Put it there. Make a mental note. This is where you will always start putting the VV. My muscles which contract are almost like an "L" (on it's side). Then, as you use the VV, and
it gets the muscles to quit reacting quite so much, do another check and see where the next set of muscles are. After the first 6 weeks or so, you will need to use it every once in awhile, I
still "use" 2 to 3 times per week, and it is still doing what I want (shhhhh). A great alternative to Botox injections and still looking natural! Dukette
List of Ingredients
- spring water
- seaweed extract [serum base]
- tripeptide 5%
*synthetic peptide, that restricts wrinkle causing facial movements all without
losing your natural expression*
- optiphen plus
SYN®-AKE – Age Killing Effect.
SYN®-AKE has been thoroughly tested and is considered to be appropriate for cosmetic applications.
• Antagonist of the muscle nicotinic acetylcholine receptor (mnAChR)
• Blocks Na+ uptake at the post-synaptic membrane
• Inhibits muscle contractions
SYN®-AKE is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the effect of Waglerin 1, a peptide that is found in the venom of the Temple Viper,
Tropidolaemus wagleri. PENTAPHARM
has developed, over the past 30 years, a unique approach for the breeding and housing of venomous snakes and particularly the Brazilian Lance Adder Bothrops moojeni whose venom is used
for therapeutic (anticoagulants, haemostatics) and diagnostic products. Currently, some 10, 000 specimens of this snake species are bred and housed at PENTAPHARM DO BRASIL, making PENTAPHARM
the largest snake breeder and keeper in the world. The long experience of PENTAPHARM in snake venom research has made possible the investigation of venom' peptides for cosmetic applications. A
special focus has been the investigation of the
Temple Viper's venom.
SYN®-AKE acts in a manner similar to that of Waglerin 1 which acts at the post-synaptic membrane. The peptide is an antagonist of the muscular nicotinic acetylcholine membrane's
receptor (mnAChR). As the muscular nicotinic ACh receptors are blocked, the ion canal remains closed. There is no uptake of Na+ and the muscles stay relaxed.
Source: McArdle, JJ, T L Lentz, V Witzemann, H Schwarz, SA Weinstein& JJ Schmidt. 1999. Waglerin-1 selectively blocks the epsilon form of the muscle nicotinic acetylcholine
receptor. J. Pharmacol. Exp. Therap.
• SYN®-AKE is an excellent anti-wrinkle active compound with a snake venom-like mode of activity.
• SYN®-AKE smoothes mimic wrinkles in a short period.
• Age killing effect particularly effective against expression lines
• Intensive anti-wrinkles care
Glycerine, Water, Dipeptide Diaminobutyroyl Benzylamide Diacetate
Efficacy Tests- in vitro tests:
The efficacy of the SYN®-AKE tripeptide (at a concentration of 0.5mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a
function of the incubation time.
SYN®-AK E peptide reduces muscle cell contraction and its action is reversible.
The measurement of the smoothing and anti-wrinkle effect of SYN®-AKE (4%) was compared to a placebo.
A cream was applied to the forehead twice daily during 28 days.
The smoothing effect (Ra) was measured on 80% of the
volunteers and the anti-wrinkle effect (Rz, Rt) measured
on 73% of the volunteers. Results showed up to -52% of wrinkle size after 28 days application!